Pair Name | Garcinol, Paclitaxel | ||
Phytochemical Name | Garcinol (PubChem CID: 5281560 ) | ||
Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Garcinol, Paclitaxel | |||
Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
Down-regulation | Cleavage | CASP3 | hsa836 | |
Down-regulation | Expression | CCNA2 | hsa890 | |
Up-regulation | Expression | CCNB1 | hsa891 | |
Down-regulation | Expression | CDC25A | hsa993 | |
Up-regulation | Expression | CDH1 | hsa999 | |
Down-regulation | Expression | CDK1 | hsa983 | |
Down-regulation | Activity | MMP2 | hsa4313 | |
Down-regulation | Activity | MMP9 | hsa4318 | |
Down-regulation | Phosphorylation | NFKBIA | hsa4792 | |
Down-regulation | Expression | PLA2G6 | hsa8398 | |
Up-regulation | Expression | PTGS1 | hsa5742 | |
Down-regulation | Expression | PTGS2 | hsa5743 | |
Down-regulation | Phosphorylation | RELA | hsa5970 | |
Down-regulation | Expression | SNAI1 | hsa6615 | |
Down-regulation | Expression | TIMP1 | hsa7076 | |
Down-regulation | Expression | TWIST1 | hsa7291 | |
Down-regulation | Expression | VEGFA | hsa7422 | |
Down-regulation | Expression | ZEB1 | hsa6935 | |
In Vitro Model | 4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 |
In Vivo Model | Balb/c mice were injected with 4T1-Luc cells (5×10⁴ in 0.2 ml of PBS) into the 4th mammary fat pad as described pre_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x005f_x0002_viously. | |||
Result | Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model |
No. | Title | Href |
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1 | Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model. Food Funct. 2017 Mar 22;8(3):1067-1079. doi: 10.1039/c6fo01588c. | Click |